Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
Most Useful Reviews
9
Sound sleep achieved
4 people found this helpful
I bought this for my son, who faced a sleep disorder causing him to reverse day and night; now, I use it myself. Consuming it guarantees a restful night’s sleep yet seems to wear off after about 6 hours. A dose taken 6 hours before waking makes a significant difference. The taste is delightful; even one drop is effective.
Read More
9
Fast asleep experience
2 people found this helpful
This is fantastic! Taking it half an hour before bed means I fall asleep almost instantly. Everyone in my family has started taking it since my husband suffers from insomnia. It greatly assists him, allowing him to fall asleep quickly and combat his sleep apnea effectively.
Read More
7.5
No more tiredness
2 people found this helpful
This product proves to be very effective; I take it 15 minutes before bed. It makes me feel very sleepy, ensuring a comfortable, prolonged slumber. I wake up refreshed without feeling tired, and I appreciate that it doesn't create an addiction. I enjoy the taste and quality; it has become a staple for addressing my sleep apnea.
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
Read More
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
Read More
7
Agomelatine shows promise for OSA
Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea.
We conducted a study to see if agomelatine, a melatonin-based drug, could help patients with obstructive sleep apnea (OSA). In this randomized and single-blind trial, seventy adults took either agomelatine or a placebo for three nights before sleep testing.
The results showed that agomelatine improved total sleep time, sleep efficiency, and reduced waking percentage compared to the control group. However, other sleep parameters did not show significant changes. Overall, agomelatine may be beneficial for those struggling with OSA.
Read More
7
REM Sleep Behavior Disorder Overview
REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary].
We explored REM sleep behavior disorder (RBD) as a complex condition that can be linked to a variety of underlying disorders. Through a literature review and insights from foundational texts, we recognized that RBD may emerge at any age and can initially appear as an isolated issue or be associated with other significant conditions like Parkinson’s and narcolepsy.
Our findings highlighted that effective management often includes melatonin or clonazepam as treatment options. Furthermore, ongoing research into the connections between RBD and other sleep disorders, such as obstructive sleep apnea, remains vital for enhancing diagnostics and treatment strategies.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 57 Reviews
7
All Reviews
Positive Reviews
Negative Reviews
9
Sound sleep achieved
4 people found this helpful
I bought this for my son, who faced a sleep disorder causing him to reverse day and night; now, I use it myself. Consuming it guarantees a restful night’s sleep yet seems to wear off after about 6 hours. A dose taken 6 hours before waking makes a significant difference. The taste is delightful; even one drop is effective.
Read More
9
Fast asleep experience
2 people found this helpful
This is fantastic! Taking it half an hour before bed means I fall asleep almost instantly. Everyone in my family has started taking it since my husband suffers from insomnia. It greatly assists him, allowing him to fall asleep quickly and combat his sleep apnea effectively.
Read More
7.5
No more tiredness
2 people found this helpful
This product proves to be very effective; I take it 15 minutes before bed. It makes me feel very sleepy, ensuring a comfortable, prolonged slumber. I wake up refreshed without feeling tired, and I appreciate that it doesn't create an addiction. I enjoy the taste and quality; it has become a staple for addressing my sleep apnea.
Read More
10
Supports restful sleep
1 people found this helpful
I bought this melatonin for my autistic son, and it’s been the best purchase I've made. It aids his sleep significantly, and he now rests well. I've already ordered more, as they are truly effective.
Read More
9
Relieves insomnia
1 people found this helpful
I’ve tried many melatonin supplements, but this one is the best. I suffer from severe insomnia and often lay awake for hours. These gummies have been a godsend. I take two at a time, which helps me sleep through the night without vivid dreams. My daughter also benefits from one each night.
Sleep apnea is a common and potentially serious sleep disorder characterized by irregular breathing patterns during sleep. Individuals with sleep apnea experience episodes of disrupted or paused breathing, which can occur multiple times throughout the night. These interruptions can last a few seconds to several minutes and often lead to fragmented sleep, which may result in excessive daytime sleepiness, irritability, and difficulty concentrating. The condition can be broadly classified into two main types: obstructive sleep apnea (OSA), caused by a blockage of the upper airway, and central sleep apnea (CSA), which occurs when the brain fails to send the proper signals to the muscles that control breathing.
The diagnosis of sleep apnea typically involves a sleep study, either conducted in a sleep clinic or at home using portable monitoring devices. Treatment options vary depending on the severity of the condition but may include lifestyle changes, the use of continuous positive airway pressure (CPAP) machines, oral appliances, or even surgery in some cases. If left untreated, sleep apnea can lead to various health complications, including cardiovascular issues, metabolic disorders, and impaired cognitive function, making it essential to consult a healthcare professional if you suspect you or someone you know may be affected by this disorder.
Melatonin is a hormone naturally produced by the pineal gland in the brain, primarily responsible for regulating sleep-wake cycles. It is often referred to as the "sleep hormone" because its levels typically rise in the evening, signaling to your body that it’s time to prepare for sleep. Conversely, melatonin levels tend to drop in the morning, helping to wake you up and feel alert. Factors such as light exposure, age, and lifestyle can affect melatonin production, which is why many people turn to melatonin supplements as a natural remedy for insomnia and sleep disorders.
Melatonin supplements can be particularly useful for those who have disrupted sleep patterns, such as shift workers or travelers experiencing jet lag. Available in various forms, including tablets and gummies, melatonin is widely regarded as a safe option for short-term use. However, it's essential to consult with a healthcare professional before starting any supplement, especially if you're pregnant, nursing, or taking other medications. While melatonin can be effective in promoting sleep, its efficacy can vary between individuals, and establishing good sleep hygiene practices, like maintaining a consistent sleep schedule and creating a comfortable sleep environment, can also significantly contribute to better sleep quality.
Based on user reviews, the time it typically takes to see results from taking this supplement for sleep apnea varies, but many users report positive effects within a short timeframe. For instance, several users mention feeling sleepy and falling asleep within 15 to 30 minutes after taking the supplement, which significantly improved their sleep quality Read ReviewRead Review. Users also highlighted the importance of timing, noting that taking the supplement closer to bedtime correlates with better results.
However, it should be noted that not all users experienced positive effects. Some reported no improvement in managing their sleep apnea despite trying various dosages Read ReviewRead Review. Overall, while many users found it helpful for achieving a restful night's sleep within about half an hour, experiences can vary, and a few have reported ineffective outcomes.
Melatonin's role in improving sleep quality for those suffering from obstructive sleep apnea (OSA) is supported by several studies. One significant double-blind trial demonstrated that melatonin supplementation resulted in better sleep quality, reduced daytime sleepiness, and increased adherence to positive airway pressure (PAP) devices among patients with OSA and insomnia. The findings across various sleep assessments like the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale suggest that melatonin could be a beneficial adjunct in the treatment of OSA, promoting better sleep outcomes for patients [2].
However, while melatonin is linked to inflammation and other complications associated with OSA, it does not completely address these issues. A study indicated that while lower melatonin levels were correlated with more severe OSA, suggesting a mediating role, it didn't directly resolve the linked inflammation or intestinal dysfunctions [1]. Therefore, while melatonin shows promise in enhancing sleep quality and treatment compliance for OSA patients, it should be considered as part of a broader therapeutic approach rather than a standalone solution.
Users report a range of improvements in their sleep symptoms after using melatonin supplements. For many, the experience includes falling asleep almost instantly after taking the recommended dosage before bed. Some users, such as those sharing their experiences with their children or partners suffering from insomnia, indicate that melatonin has substantially improved their ability to fall asleep and achieve deeper, uninterrupted sleep. For example, one user noted their son now sleeps well after having struggled with sleep disorders, demonstrating how effective the product can be for different age groups Read Review. Similarly, others have expressed feeling refreshed upon waking and highlighted the pleasant taste and absence of addictive properties as major advantages Read Review.
However, it's important to note that individual results can vary significantly. While several users reported significant improvements, some experienced no benefits, and a few even reported adverse effects like insomnia and unrestful nights despite trying higher dosages Read ReviewRead Review. Overall, the consensus among those who found it effective is that it provided a much-needed solution for managing sleep issues, particularly for sleep apnea, but the variability in outcomes suggests that it may not be a universal remedy Read Review.
Users report mixed experiences when combining this melatonin supplement with other products for managing sleep apnea. Some have found that it significantly aids in falling asleep quickly and improving sleep quality. One user noted that their husband, who suffers from insomnia and sleep apnea, benefits from taking it before bed, allowing him to combat his sleep issues effectively Read Review. Additionally, another user highlighted the effectiveness of the supplement in regulating their sleep apnea after taking two pills, appreciating how they fell asleep quickly thereafter Read Review.
However, not all experiences were positive. Several users reported that the supplement did not help with their sleep apnea or even worsened their sleep issues. For instance, multiple users tried higher doses but still found no benefit in managing their sleep apnea, indicating that the product might not work universally for everyone Read ReviewRead Review. Even users who previously experienced initial benefits also reported diminished effectiveness over time. This suggests individuals considering melatonin for sleep apnea should approach with caution, as results may vary significantly based on personal physiology and circumstances.
When it comes to using melatonin as a treatment for sleep apnea, recent research suggests that a dose of 10 mg may be optimal. In a double-blind trial involving 30 patients with obstructive sleep apnea and insomnia, participants who received 10 mg of melatonin reported significantly better sleep quality, reduced daytime sleepiness, and improved adherence to their continuous positive airway pressure (CPAP) therapy compared to those who received a placebo. The study highlighted substantial gains on various sleep assessment scales, making a compelling case for melatonin as a beneficial adjunct therapy for this challenging patient population [2].
However, while melatonin shows promise in enhancing sleep quality and compliance with treatment, it is essential to remember that it does not address all complications associated with sleep apnea. Research indicates that higher severity of obstructive sleep apnea is linked to lower levels of melatonin and heightened inflammation and intestinal dysfunction, but melatonin doesn’t appear to resolve these issues directly [1]. Therefore, while the 10 mg dose can enhance sleep quality for those struggling with sleep apnea, a comprehensive treatment plan should involve consulting healthcare professionals for a holistic approach to managing the condition.
7.5
No more tiredness
2 people found this helpful
This product proves to be very effective; I take it 15 minutes before bed. It makes me feel very sleepy, ensuring a comfortable, prolonged slumber. I wake up refreshed without feeling tired, and I appreciate that it doesn't create an addiction. I enjoy the taste and quality; it has become a staple for addressing my sleep apnea.
9
Outstanding effectiveness
1 people found this helpful
I've ordered this product multiple times as it’s very effective and tasty. Within half an hour of taking it, I fall asleep soundly and wake up feeling rejuvenated. I highly recommend it for those with sleep issues.
0
Did not help sleep
I'm sorry, but this product did not assist me with sleep. I tried it every night without success in treating my sleep apnea.
0
Ineffective for sleep
Sadly, despite doubling the dosage, this product did not help me sleep at all or manage my sleep apnea effectively.
10
Supports restful sleep
1 people found this helpful
I bought this melatonin for my autistic son, and it’s been the best purchase I've made. It aids his sleep significantly, and he now rests well. I've already ordered more, as they are truly effective.
0
Insomnia experienced
Unfortunately, this product caused me terrible insomnia. I tried it twice hoping to achieve deep sleep, but it had the opposite effect.
9
Sleep problems addressed
3 people found this helpful
I struggled to sleep for more than three hours due to extreme stress. After months of trying this product, I can now sleep for a regular 8 hours, which greatly improves both my mood and my sleeping patterns. I highly recommend it for others battling sleep issues, including sleep apnea.
9
Fast asleep experience
2 people found this helpful
This is fantastic! Taking it half an hour before bed means I fall asleep almost instantly. Everyone in my family has started taking it since my husband suffers from insomnia. It greatly assists him, allowing him to fall asleep quickly and combat his sleep apnea effectively.
9
Sleep regulated
I was very satisfied; it regulates my sleep apnea as soon as I take two pills, and I fall asleep within half an hour.
9.5
Melatonin improves sleep apnea outcomes
Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.
We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.
The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.
Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.
7
Melatonin's role in sleep apnea
Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients.
We explored how melatonin, known for its anti-inflammatory properties, interacts with obstructive sleep apnea (OSA) and related health issues.
In a study of 235 men experiencing sleep problems, we found that higher OSA severity correlated with lower melatonin levels and increased markers of intestinal barrier dysfunction and inflammation.
Melatonin appeared to mediate these relationships, explaining a significant portion of the connection between apnea severity and these harmful conditions. However, the overall results suggest that while melatonin is connected to inflammation and intestinal issues in OSA, it does not appear to solve these complications.
References
Wei Z, Shen H, Wang F, Huang W, Li X, et al. Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients. Ann Med. 2024;56:2361825. 10.1080/07853890.2024.2361825
Motlaq TM, Rahimi B, Amini S. Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial. J Pharm Health Care Sci. 2024;10:25. 10.1186/s40780-024-00347-9
Dastan F, Gholizadeh Niari B, Adimi Naghan P, Barati S, Eskandari R. Evaluating the Effects of Agomelatine on Polysomnography Parameters in Patients with Obstructive Sleep Apnea. J Pharm Pharm Sci. 2023;25:418. 10.18433/jpps33252
Schenck CH. REM sleep behavior disorder as a complex condition with heterogeneous underlying disorders: clinical management and prognostic implications [Commentary]. Sleep Breath. 2022;26:1289. 10.1007/s11325-022-02574-6